Ly6c and ly6g antibody cross reactivity12/17/2023 ![]() Ly6 family proteins have different functions depending on expression in different tissues. įurther, the Ly6 family proteins are also expressed, for example, by sperm, neurons, keratinocytes and epithelial cells. Many Ly6 family members are expressed in hematopoietic precursors and differentiated hematopoietic cells in a lineage-specific manner and making them useful cell surface markers for leukocytes, facilitating identification of distinct leukocyte sub-population. Expression Īlthough the Ly6 family members share a common structure, their expression varies in different tissues and is regulated depending on the stage of cell differentiation. īased on their subcellular localization, these proteins are classified as GPI-anchored to the cell membrane or secreted. The LU domain consists of 60-80 AA and contains 10 cysteines arranged in a specific pattern that allows the creation of 5 disulfide bridges which in turn allow the formation of a three-fingered (3F) structural motif. Typically, they contain one LU domain, but some members of the family Ly6 proteins are characterized by the LU domain. The first exon encodes the signal peptide, Exons 2 and 3 encode the LU domain, and exon 3 also encodes the GPI anchor. Genes encoding Ly6 proteins with one LU domain consist of 3 exons and 2 introns. In the murine genome family members are located on chromosomes 17, 15, 9 and 7, respectively. Genes encoding human Ly6 family members are located in clusters on chromosomes 6, 8, 11 and 19. This family was discovered in the 1970s, and these proteins are still used as markers of distinct stage of leukocyte differentiation. Their overexpression or dysregulation, for example due to point mutations, is associated with tumorogenesis and autoimmune diseases. For example, they are involved in cell proliferation, cell migration, cell–cell interactions, immune cell maturation, macrophage activation, and cytokine production. ![]() They are expressed in various types of tissues and their expression dependent on the stage of cell differentiation. ![]() Depending on which tissues they are expressed in, LY6 family members have different roles. A total of 35 human and 61 mouse Ly6 family members have been identified. These proteins are GPI-anchored to the cell membrane or are secreted. Ly6 are cysteine-rich proteins that form disulfide bridges and contain a LU domain. Ly6 also known as lymphocyte antigen 6 or urokinase-type plasminogen activator receptor (uPAR) is family of proteins that share a common structure but differ in their tissue expression patterns and function. ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |